The makeup free singer apologised to fans saying she was too unwell to perform at the concert in Phoenix, Arizona, yesterday.
She was due to appear for a second night at the 18,000-seat Talking Stick Resort Arena as part of her sell-out 2016 world tour. In a video posted on Instagram, a visibly emotional Adele said: "I'm really, really sorry. I've had a cold for a couple of days and I've been pushing through it.
"I did my show last night and I loved it but I pushed too hard and my cold has gotten the better of me."
She added: "I've enjoyed my tour so much and cancelling shows has not been something I want to do.
"I'm so sorry to let you down. I know lots of people will be flying in from all over. It's the last thing I want to do but I have to look after myself because I've got so many more shows to do.
"I will reschedule this show, I promise you. And I will come back and I'll smash it for you."