Nykea Aldridge became the unintended victim of a gang shooting in the city's Parkway Gardens neighborhood on Friday afternoon as she was pushing her child in a stroller.
The mother-of-four, who had recently had a baby, was gunned down in crossfire just 24 hours after the Chicago Bulls player discussed the shocking violence with ESPN.
The Chicago native and 12-time All Star later confirmed her tragic death on Twitter.
He wrote: 'My cousin was killed today in Chicago. Another act of senseless gun violence. 4 kids lost their mom for NO REASON. Unreal.'
Wade followed the heartbreaking message with: '#EnoughIsEnough.'
Aldridge, 32, was walking from Dulles School when two men approached another man and opened fire.
Reports suggest she had just enrolled her child to start classes. The infant wasn't hurt and was taken into custody by a family member at the scene.
According to ABC 7 Chicago, she was struck in the head and arm by crossfire.
She was taken to Stroger Hospital where she was pronounced dead.
Wade's mother, Pastor Jolinda Wade said: 'Just sat up on a panel yesterday, The Undefeated, talking about the violence that's going on within our city of Chicago, never knowing that the next day we would be the ones that would be actually living and experiencing it.'
Two people are being questioned by police. The shooting remains under investigation.