Sharper, 40, had earlier reached a multi-jurisdiction plea deal related to allegations he drugged and raped as many as 16 women in four states.
He was in tears as he sat in the courtroom, and apologized '1,000 times' to his victims, before adding his victims, 'didn't deserve anything, being a part of my heinous decisions.'
Moments before the 220-month sentence was handed down, one of the former NFL player's victims addressed the court. She finished her comments by telling Sharper to 'go to hell.'
'You can't do what you did to me to any other girl and get away with it,' the woman said. 'Not under my watch.'
The victim also told the court she took medication for three months after the attack to ensure she did not contract HIV.
Sentencing was originally slated for June, but Judge Jane Triche Milazzo rejected the nine-year prison sentence prosecutors recommended under the plea deal and doubled it.
Facing allegations of drugging and raping women, Sharper pleaded guilty or no-contest to charges in federal court in New Orleans and state courts in Louisiana, Arizona, California and Nevada.
The 40-year-old pleaded guilty in federal court to three counts of distributing drugs with rape as the aim.
He or his friend Brandon Licciardi, a former sheriff's deputy in neighboring St. Bernard Parish, put anti-anxiety drugs or sedatives into women's drinks so they could rape them, according to a 15-page statement signed as part of that plea.
Charges around the country involve nine victims, but Milazzo has said in court that there may be as many as 16.
Milazzo has scheduled sentencing Oct. 13 for Licciardi and a second New Orleans co-defendant, Erik Nunez.
Like Sharper, Licciardi and Nunez admitted distributing drugs with the intent to commit rape.
Their plea agreements say Licciardi has accepted a 17-year sentence, with 10 years for Nunez.
Sharper, a six-time All-Pro safety and five-time Pro Bowl selection during a 14-year career, played for the Green Bay Packers, the Minnesota Vikings and the New Orleans Saints team that won the 2010 Super Bowl.
He ended a 14-year career in 2011.
He was working as an NFL network analyst when women began telling police in several cities similar stories of blacking out while drinking with him and waking up groggy to find they had been sexually abused.