Ms Reno, 78, was at the centre of several political crises while serving under President Bill Clinton between 1993 and 2001.
She was criticised for a deadly raid on the Branch Davidian cult compound in Waco, Texas after just weeks in office.
Sect leader David Koresh and some 80 followers were killed during the raid.
Questions were asked afterwards about the legality of the FBI raid and why it was that so many people were killed.
Ms Reno survived the aftermath of the raid to become the longest-serving attorney-general in the 20th Century from 1993-2001 - and one of President Clinton's most trusted cabinet members.
She also continued to work despite being diagnosed in 1995 with Parkinson's disease, which caused trembling in both her arms.
After Waco, Ms Reno played a role in some of the more high-profile controversies and scandals that rocked the Clinton administration