At least six children were killed, and many are injured. One nine year old boy had left early for school in a neighbouring village and ran back to his home to find his entire family killed.
The Boeing 747 went down near Manas airport as it tried to land in dense fog, officials said.
According to the airport administration, the plane was supposed to make a stopover at Manas, near the capital city Bishkek, on its way from Hong Kong to Istanbul.
It crashed when trying to land in poor visibility at 7:31 local time (01:31 GMT).
The doomed plane damaged 15 buildings in the village, said Mukhammed Svarov, head of crisis management centre at the emergencies ministry.
Rescue workers have recovered the body of a pilot and villagers, with them still at the crash scene recovering more bodies.