Between songs, the Canadian rapper used his platform to take a swipe at the newly elected President, telling the crowd "it's on us to keep this s**t together".
He ranted: “Every day I wake up, I see all this bulls**t going on in the world. People trying to tear us apart, people trying to make us turn against each other.
“My proudest moment... if you take a look around in this room, you’ll see people from all races and all places - and all we did tonight was come inside this building, show love, celebrate life, more life, and more music.
"And I just want you to understand if you ever thought for a second that any one man is going to tear this world apart you’re out of your motherfucking mind. It’s on us to keep this s**t together. F**k that man.”
On the same day, Lady Gaga also took a subtle swipe at Trump during her Super Bowl half-time show.
The singer's performance had promised to be politically charged in the wake of protests against Trump.